High prevalence of S. pyogenes Cas9-specific T cell sensitization within the adult human population - A balanced effector/regulatory T cell response
D. L. Wagner, L. Amani, D. J. Wendering, P. Reinke, H.-D. Volk, M. Schmueck-Henneresse
The paper identifies a widespread memory/effector T cell response and regulatory T cell presence against SpCas9 in healthy humans, with implications for gene therapy.
bioRxiv · Apr 4, 2018Immunology