Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation
C. Vasquez, M. Patel, A. Sivaramakrishnan, C. Bekeova, L. Anderson-Pullinger, N. Wang, H.-Y. Tang, E. L. Seifert
This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.
bioRxiv · Jun 12, 2020 · PreprintBiochemistry