J. M. Herrmann

The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria

The paper identifies ER-mitochondria contact sites as essential for the ER-SURF pathway's role in transferring mitochondrial precursor proteins from the ER to mitochondria.

Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins

The paper develops ppTPP to study mitochondrial dysfunction's effects on proteome stability and abundance, revealing group-specific response patterns in eukaryotic cells.

MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol

The paper identifies MitoStores as cytosolic granules that store mitochondrial precursors in yeast, controlled by chaperones Hsp42 and Hsp104 to prevent toxicity.

The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex

This study shows that Ubc8 promotes mitochondrial protein import by enhancing TOM complex assembly during metabolic transitions in yeast.

The ER transmembrane complex (EMC) can functionally replace the Oxa1 insertase in mitochondria

The paper shows that the ER EMC complex can replace Oxa1 in yeast mitochondria, restoring respiratory function and inserting mitochondrial and nuclear proteins.

The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering non-imported proteins

The paper shows that mitochondrial membrane proteins accumulate in the endoplasmic reticulum during import defects, triggering the UPRER to maintain protein homeostasis.

Mitochondrial ribosomal proteins developed unconventional mitochondrial targeting signals due to structural constraints

The paper identifies internal mitochondrial targeting signals in yeast mitochondrial ribosomal proteins, showing that 30% of them use non-conventional signals not reliably predicted by existing methods.

Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.

The mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.

More than just a ticket canceller: The mitochondrial processing peptidase matures complex precursor proteins at internal cleavage sites

The paper shows that mitochondrial processing peptidase (MPP) cleaves precursor proteins at internal sites, not just N-terminal presequences, using the Arg5,6 polyprotein as a model.

Multiple acyl-CoA thioesterases occupy distinct functional niches within the mitochondrial matrix

The paper identifies distinct functional roles of mitochondrial Acot enzymes based on substrate specificity and CoA inhibition, revealing their roles in regulating beta-oxidation and preventing lipotoxicity.