H.-Y. Tang

Steric-free bioorthogonal profiling of cellular acetylation and glycosylation via a fluorine-selenol displacement reaction (FSeDR)

This paper introduces a fluorine-selenol displacement reaction (FSeDR) to label and image acetylation and glycosylation, and uses it with SILAC proteomics to profile acetylation substrates in prostate cancer cells.

Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation.

This study identifies elevated fungal translocation markers in PASC patients, which induce NF-κB inflammation through Dectin-1 signaling.

Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

This study identifies posttranslational protein signatures in COVID-19 patient plasma through proteomic analysis, revealing changes in phosphorylation, glycosylation, and arginylation.

Differential N-terminal processing of beta and gamma actin in vivo

The paper identifies specific N-terminal processing of beta actin in vivo, showing its impact on actin function and cellular behavior.

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.

Phospholipid Metabolism Is Associated with HIV Rebound Upon Treatment Interruption

This study links phospholipid and lysophospholipid levels to faster HIV rebound after treatment interruption, suggesting their role in viral persistence and inflammation.

Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction (FTDR)

This paper introduces a novel bioorthogonal reaction, FTDR, for selectively labeling acetylation substrates using fluorine-thiol displacement, enabling detection and imaging of acetylated proteins.

Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation

This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.

A Membrane-Bound Cytochrome Enables Methanosarcina acetivorans to Conserve Energy to Support Growth from Extracellular Electron Transfer

This study shows Methanosarcina acetivorans conserves energy via extracellular electron transfer using a membrane-bound cytochrome, MmcA, and identifies its role in electron transport pathways.

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.