Production of a Highly Immunogenic Antigen from SARS-CoV-2 by Covalent Coupling of the Receptor Binding Domain of Spike Protein to a Multimeric Carrier
Argentinian AntiCovid Consortium, P. M. Berguer, M. Blaustein, L. Bredeston, P. O. Craig, C. D'Alessio, F. Elias, P. C. Farre, N. B. Fernandez, H. G. Gentili, Y. Gandola, J. Gasulla, G. E. Gudesblat, M. G. Herrera, L. I. Ibanez, , A. M. Zelada
This paper shows that coupling multiple SARS-CoV-2 RBD units to a multimeric carrier protein enhances immune response, leading to higher neutralizing antibody titers.
bioRxiv · Apr 25, 2021 · PreprintBiochemistry