Author

N. B. Fernandez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Santos· 3 shared M. F. Pignataro· 3 shared M. G. Herrera· 3 shared N. Rubinstein· 3 shared A. D. Nadra· 2 shared A. M. Zelada· 2 shared Argentinian AntiCovid Consortium· 2 shared C. D'Alessio· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

J. Santos

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RUNX1 is regulated by androgen receptor to promote cancer stem markers and chemotherapy resistance in triple negative breast cancer.

N. B. Fernandez, S. M. Sosa, J. T. Roberts, M. S. Recouvreux, L. Rocha-Viegas, J. L. Christenson, N. S. Spoelstra, F. L. Couto, A. R. Raimondi, J. K. Richer, N. Rubinstein

This study shows that RUNX1 is regulated by androgen receptor in TNBC, promoting cancer stem cell markers and chemotherapy resistance.

bioRxiv · Nov 12, 2022Cancer Biology

Selection of Synthetic Proteins to Modulate the Human Frataxin Function

M. F. Pignataro, M. G. Herrera, N. B. Fernandez, M. Aran, F. Bataglini, J. Santos

This study selects a synthetic protein, Affi_224, that modulates frataxin function with nanomolar affinity, showing potential for therapeutic applications in Friedreichs Ataxia.

bioRxiv · Feb 11, 2022Biochemistry

Production of a Highly Immunogenic Antigen from SARS-CoV-2 by Covalent Coupling of the Receptor Binding Domain of Spike Protein to a Multimeric Carrier

Argentinian AntiCovid Consortium, P. M. Berguer, M. Blaustein, L. Bredeston, P. O. Craig, C. D'Alessio, F. Elias, P. C. Farre, N. B. Fernandez, H. G. Gentili, Y. Gandola, J. Gasulla, G. E. Gudesblat, M. G. Herrera, L. I. Ibanez, , A. M. Zelada

This paper shows that coupling multiple SARS-CoV-2 RBD units to a multimeric carrier protein enhances immune response, leading to higher neutralizing antibody titers.

bioRxiv · Apr 25, 2021 · PreprintBiochemistry

Structural and Functional Comparison of SARS-CoV-2-Spike Receptor Binding Domain Produced in Pichia pastoris and Mammalian Cells

Argentinian AntiCovid Consortium, C. R. Arbeitman, G. Auge, M. Blaustein, L. Bredeston, E. S. Corapi, P. O. Craig, L. A. Cossio, L. Dain, C. D'Alessio, F. Elias, N. B. Fernandez, J. Gasulla, N. Gorojovsky, G. E. Gudesblat, , A. M. Zelada

This study compares the structural and functional properties of SARS-CoV-2 Spike RBD produced in yeast and mammalian cells, finding similar stability but greater heterogeneity in yeast-produced RBD.

bioRxiv · Sep 17, 2020 · PreprintBiochemistry