Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
Y. Lin, Y. Fichou, A. P. Longhini, L. C. Llanes, Y. Yin, G. C. Bazan, K. S. Kosik, S. Han
This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.
bioRxiv · Aug 5, 2020Biophysics