NRF2-dependent metabolic reprogramming is required for tumor recurrence following oncogene inhibition
D. B. Fox, R. Lupo, L. C. Noteware, R. Newcomb, J. Liu, J. W. Locasale, M. D. Hirschey, J. V. Alvarez
This study identifies NRF2-driven metabolic reprogramming as essential for breast cancer recurrence after oncogene inhibition and shows it can be targeted with glutaminase inhibitors.
bioRxiv · Jan 8, 2019 · PreprintCancer Biology