Author

M. D. Hirschey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:metabolomics· 5 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Organism:C. elegans· 1

Frequent Co-Authors

D. P. Bhatt· 2 shared J. Liu· 2 shared O. R. Ilkayeva· 2 shared A. Cheema· 1 shared A. E. Adams· 1 shared A. Kalita· 1 shared A. Z. Rosenberg· 1 shared B. A. Jones· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

D. P. Bhatt

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Author profile →

5 papers

Recent·Most cited

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

K. Myakala, X. Wang, N. V. Shults, B. A. Jones, X. Yang, A. Z. Rosenberg, B. Ginley, P. Sarder, L. Brodsky, Y. Jang, C. H. Na, Y. Chi, X. Zhang, U. Guha, C. Wu, , M. Levi

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

bioRxiv · Dec 5, 2021Pathology

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

J. P. Rooney, K. A. Hershberger, E. A. Turner, L. J. Donoghue, L. L. Maurer, I. T. Ryde, J. J. Kim, R. Joglekar, J. D. Hibshman, L. L. Smith, D. P. Bhatt, O. R. Ilkayeva, M. D. Hirschey, J. N. Meyer

This study shows that early-life mitochondrial DNA damage in C. elegans causes lifelong energy production deficits through redox signaling mechanisms.

bioRxiv · Nov 25, 2020Cell Biology

A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism

E. E. Hesles, D. L. Smith, N. S. Maqani, M. B. Wierman, M. D. Sutcliffe, R. D. Fine, A. Kalita, S. M. Santos, M. J. Muehlbauer, J. R. Bain, K. A. Janes, J. L. Hartman, M. D. Hirschey, J. S. Smith

bioRxiv · Jul 13, 2020Cell Biology

Deglutarylation of GCDH by SIRT5 controls lysine metabolism in mice

D. P. Bhatt, C. A. Mills, K. A. Anderson, B. J. Henriques, T. G. Lucas, S. Francisco, J. Liu, O. R. Ilkayeva, A. E. Adams, S. R. Kulkarni, D. S. Backos, P. A. Grimsrud, C. M. Gomes, M. D. Hirschey

This study identifies glutarylation of GCDH by glutaryl-CoA and shows SIRT5 deglutarylates GCDH, restoring its function and regulating lysine metabolism in mice.

bioRxiv · Jun 28, 2020 · PreprintBiochemistry

NRF2-dependent metabolic reprogramming is required for tumor recurrence following oncogene inhibition

D. B. Fox, R. Lupo, L. C. Noteware, R. Newcomb, J. Liu, J. W. Locasale, M. D. Hirschey, J. V. Alvarez

This study identifies NRF2-driven metabolic reprogramming as essential for breast cancer recurrence after oncogene inhibition and shows it can be targeted with glutaminase inhibitors.

bioRxiv · Jan 8, 2019 · PreprintCancer Biology