KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
T. H. Tran, A. H. Chan, L. C. Young, L. Bindu, C. Neale, S. Messing, S. Dharmaiah, T. Taylor, J.-P. Denson, D. Esposito, D. V. Nissley, A. G. Stephen, F. McCormick, D. K. Simanshu
The paper determines crystal structures of KRAS mutants bound to RAF1 domains, revealing molecular interactions critical for RAS-mediated RAF activation.
bioRxiv · Jul 31, 2020Biophysics