Author

A. H. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Bertero· 1 shared A. G. Stephen· 1 shared A. Kulkarni· 1 shared A. M. Fenix· 1 shared A. Truong· 1 shared B. R. Conklin· 1 shared C. E. Murry· 1 shared C. Neale· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCell Biology

A. Bertero

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

A. H. Chan, K. Vezyrgiannis, J. B. Von Pein, X. Wang, L. I. Labzin, D. Boucher, K. Schroder

This study identifies that caspase-4 dimerisation and D289 auto-processing enable direct cleavage of pro-IL-1β, independent of the NLRP3 inflammasome.

bioRxiv · Jan 5, 2023Immunology

Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

A. M. Fenix, Y. Miyaoka, A. Bertero, S. Blue, M. J. Spindler, K. K. B. Tan, J. A. Perez-Bermejo, A. H. Chan, S. J. Mayer, T. Nguyen, C. R. Russell, P. Lizarraga, A. Truong, P.-L. So, A. Kulkarni, , N. Salomonis

This study investigates how RBM20 mutations affect splicing and ribonucleoprotein granules in cardiomyopathy, revealing distinct pathogenic mechanisms between missense and knockout mutations.

bioRxiv · Jun 2, 2021Cell Biology

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

T. H. Tran, A. H. Chan, L. C. Young, L. Bindu, C. Neale, S. Messing, S. Dharmaiah, T. Taylor, J.-P. Denson, D. Esposito, D. V. Nissley, A. G. Stephen, F. McCormick, D. K. Simanshu

The paper determines crystal structures of KRAS mutants bound to RAF1 domains, revealing molecular interactions critical for RAS-mediated RAF activation.

bioRxiv · Jul 31, 2020Biophysics