Author

J.-P. Denson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. Esposito· 3 shared S. Messing· 3 shared T. Taylor· 3 shared J. Mehalko· 2 shared K. Sadtler· 2 shared K. Snead· 2 shared M. Drew· 2 shared V. Wall· 2 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

D. Esposito

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays

J. Mehalko, M. Drew, K. Snead, J.-P. Denson, V. Wall, T. Taylor, K. Sadtler, S. Messing, W. Gillette, D. Esposito

The paper improves the production of SARS-CoV-2 spike RBD for serology assays by optimizing DNA constructs, purification parameters, and demonstrating the role of a carboxyterminal tag in sensitivity.

bioRxiv · Nov 18, 2020Biochemistry

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

T. H. Tran, A. H. Chan, L. C. Young, L. Bindu, C. Neale, S. Messing, S. Dharmaiah, T. Taylor, J.-P. Denson, D. Esposito, D. V. Nissley, A. G. Stephen, F. McCormick, D. K. Simanshu

The paper determines crystal structures of KRAS mutants bound to RAF1 domains, revealing molecular interactions critical for RAS-mediated RAF activation.

bioRxiv · Jul 31, 2020Biophysics

Optimizing high-yield production of SARS-CoV-2 soluble spike trimers for serology assays

D. Esposito, J. Mehalko, M. Drew, K. Snead, V. Wall, T. Taylor, P. Frank, J.-P. Denson, M. Hong, G. Gulten, K. Sadtler, S. Messing, W. Gillette

This study improves the yield of SARS-CoV-2 spike protein for serology assays by optimizing expression and purification parameters, achieving 5 mg/L production.

bioRxiv · May 27, 2020Biochemistry