S. Henderson

Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity

The paper investigates how monocyte differentiation in adult skin leads to Langerhans cell identity through intrinsic and extrinsic factors.

Sampling biases obscure the early diversification of the largest living vertebrate group

The paper examines sampling biases in the Palaeozoic actinopterygian fossil record and shows how they obscure early diversification patterns.

Utilizing multi-objective decision support tools for protected area selection

This paper presents a global decision support tool for selecting protected areas by balancing multiple conservation objectives and highlighting trade-offs among them.

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

The Th1 cell regulatory circuitry is largely conserved between human and mouse

The study compares T-bet target gene regulation between human and mouse, finding most genes are conserved despite species-specific pathogen exposure.

High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

A population of CD4+ T cells with a naive phenotype stably polarized to the TH1 lineage

The paper identifies a novel CD4+ T cell population with naive markers that are stably polarized to the TH1 lineage and resistant to repolarization.

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

Human and mouse essentiality screens as a resource for disease gene discovery

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression.

This paper develops an antibody targeting ICOS that improves the TEFF:TReg ratio and induces tumour regression in preclinical models.

Role for Merlin/NF2 in transcription elongation through interaction with the PAF complex

This study shows Merlin interacts with the PAF complex to regulate transcription elongation, linking cell-cell adhesion to tumor suppression.