Author

D. V. Nissley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Esposito· 3 shared F. McCormick· 3 shared S. Messing· 3 shared A. G. Stephen· 2 shared D. K. Simanshu· 2 shared M. Drew· 2 shared A. A. Gorfe· 1 shared A. H. Chan· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

D. Esposito

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome

D. A. Bonsor, P. Alexander, K. Snead, N. Hartig, M. Drew, S. Messing, L. I. Finci, D. V. Nissley, F. McCormick, D. Esposito, P. Rodriguez-Viciana, A. G. Stephen, D. K. Simanshu

The paper presents the structure of the SHOC2-MRAS-PP1C complex and shows how it regulates RAF activation and is linked to Noonan syndrome mutations.

bioRxiv · May 10, 2022Biophysics

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

T. H. Tran, A. H. Chan, L. C. Young, L. Bindu, C. Neale, S. Messing, S. Dharmaiah, T. Taylor, J.-P. Denson, D. Esposito, D. V. Nissley, A. G. Stephen, F. McCormick, D. K. Simanshu

The paper determines crystal structures of KRAS mutants bound to RAF1 domains, revealing molecular interactions critical for RAS-mediated RAF activation.

bioRxiv · Jul 31, 2020Biophysics

Biochemical and structural analysis reveals the Neurofibromin (NF1) protein forms a high-affinity dimer

M. Sherekar, S.-W. Han, R. Ghirlando, S. Messing, M. Drew, P. Juneja, H. O'Neill, C. Stanley, D. Bhowmik, A. Ramanathan, S. Subramaniam, D. V. Nissley, W. Gillette, F. McCormick, D. Esposito

This study shows Neurofibromin forms a high-affinity dimer through biochemical and structural analysis, with implications for its function in RAS-MAPK signaling.

bioRxiv · Sep 5, 2019 · PreprintBiochemistry

Membrane curvature sensing of the lipid-anchored K-Ras small GTPases

H. Liang, H. Mu, F. Jean-Francois, B. Lakshman, S. Sarkar-Banerjee, Y. Zhuang, Y. Zeng, W. Gao, D. V. Nissley, A. A. Gorfe, W. Zhao, Y. Zhou

This study shows that K-Ras and H-Ras isoforms respond differently to plasma membrane curvature, with K-Ras favoring less curved membranes and H-Ras favoring more curved membranes, mediated by phospholipid sorting.

bioRxiv · Dec 10, 2018 · PreprintBiochemistry