Author

L. Di Michele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

P. Cicuta· 3 shared L. Malouf· 2 shared R. Rubio Sanchez· 2 shared A. Huyghebaert· 1 shared A. Leathers· 1 shared A. Wang· 1 shared B. M. Mognetti· 1 shared C. Bonfio· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiophysics

P. Cicuta

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sculpting DNA-based synthetic cells through phase separation and phase-targeted activity

L. Malouf, D. A. Tanase, G. Fabrini, M. Paez-Perez, A. Leathers, M. J. Booth, L. Di Michele

This paper demonstrates the creation of synthetic cells using DNA nanostructures that form compartmentalized architectures with targeted activities through phase separation and chemical modifications.

bioRxiv · Mar 17, 2023Biophysics

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

F. Raguseo, A. Huyghebaert, J. Li, R. Balendra, m. Petric Howe, Y. Wang, D. M. Vadukul, D. Tanase, T. E. Maher, L. Malouf, R. Rubio Sanchez, F. A. Aprile, Y. Elani, R. Patani, L. Di Michele, M. Di Antonio

This study shows that C9orf72 hexanucleotide repeat expansions form RNA condensates via multimolecular G-quadruplexes, suggesting a therapeutic target for ALS/FTD.

bioRxiv · Jan 31, 2023Biochemistry

DNA-origami line-actants control domain organisation and fission in synthetic membranes

R. Rubio-Sanchez, B. M. Mognetti, P. Cicuta, L. Di Michele

This paper introduces DNA-origami line-actants that control membrane domain organisation and fission in synthetic systems.

bioRxiv · Jan 9, 2023Biophysics

Thermal oscillations enable reshuffling of genetic material in a primitive cell cycle

R. Rubio Sanchez, D. O'Flaherty, A. Wang, F. Coscia, L. Di Michele, P. Cicuta, C. Bonfio

This paper proposes a primitive cell cycle driven by thermal oscillations that enables genetic material reshuffling in prebiotic fatty acid vesicles, leading to the emergence of functional RNA-containing protocells.

bioRxiv · Apr 1, 2021 · PreprintBiophysics

A modular, dynamic, DNA-based platform for regulating cargo distribution and transport between lipid domains

R. Rubio-Sánchez, S. Eizagirre Barker, M. Walczak, P. Cicuta, L. Di Michele

This paper introduces a DNA-based platform that regulates cargo distribution between lipid domains using modular, dynamic DNA nanostructures.

bioRxiv · Mar 2, 2021Biophysics