F. Coscia

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

Serialized On-grid Lift-In Sectioning for Tomography (SOLIST)

The paper introduces SOLIST, a method that improves cryo-electron tomography by increasing throughput, reducing ice contamination, and enhancing sample stability for various specimens.

Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics

Slice-PASEF improves tandem MS sensitivity for low-sample proteomics, enabling applications like single-cell proteomics and drug screens.

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

The paper identifies coronavirus-host protein interaction motifs, revealing SARS-CoV-2 specific mechanisms and a peptide-based inhibitor that blocks infection.

Thermal oscillations enable reshuffling of genetic material in a primitive cell cycle

This paper proposes a primitive cell cycle driven by thermal oscillations that enables genetic material reshuffling in prebiotic fatty acid vesicles, leading to the emergence of functional RNA-containing protocells.

Molecular Response to PARP1 Inhibition in Ovarian Cancer Cells as Determined by Mass Spectrometry Based Proteomics

This study uses proteomics to analyze how ovarian cancer cells respond to PARP1 inhibition, identifying adaptive resistance mechanisms and potential therapeutic targets.

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

The paper creates a spatially and cell-type resolved proteomic atlas of healthy human skin, quantifying 10,701 proteins across different locations and cell types.

Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disorders

The paper shows that gain-of-function mutations in FAM111A and FAM111B enhance protease activity, leading to DNA replication and transcription suppression and cell death, contributing to genetic disorders.