The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes
F. Raguseo, A. Huyghebaert, J. Li, R. Balendra, m. Petric Howe, Y. Wang, D. M. Vadukul, D. Tanase, T. E. Maher, L. Malouf, R. Rubio Sanchez, F. A. Aprile, Y. Elani, R. Patani, L. Di Michele, M. Di Antonio
This study shows that C9orf72 hexanucleotide repeat expansions form RNA condensates via multimolecular G-quadruplexes, suggesting a therapeutic target for ALS/FTD.
bioRxiv · Jan 31, 2023Biochemistry