HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis
C. Loiseau, D. Brites, M. Reinhard, K. Zuercher, S. Borrell, M. Ballif, L. Fenner, H. Cox, L. K. Rutaihwa, R. J. Wilkinson, M. Yotebieng, E. J. Carter, A. Abimiku, O. Marcy, E. Gotuzzo, , S. Gagneux
The paper analyzes drug-resistant Mtb genomes from HIV coinfected and HIV negative patients, finding that HIV coinfected patients have more low fitness rpoB variants in rifampicin-resistant strains.
bioRxiv · Jul 20, 2020Evolutionary Biology