bioRxivEvolutionary Biology
HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis
C. Loiseau, D. Brites, M. Reinhard, K. Zuercher, S. Borrell, M. Ballif, L. Fenner, H. Cox, L. K. Rutaihwa, R. J. Wilkinson, M. Yotebieng, E. J. Carter, A. Abimiku, O. Marcy, E. Gotuzzo, A. Avihingsanon, N. Zetola, B. Doulla, E. C. Boettger, M. Egger, S. Gagneux
Abstract
We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.
- organism: human
- assay: whole-genome sequencing
- research focus: variant calling
- approach: statistical model
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