C. Loiseau

Evolution of immune genes in island birds: reduction in population sizes can explain island syndrome

This study investigates immune gene evolution in island birds, finding demographic effects reduce genetic diversity and selection efficacy, but relaxed selection due to reduced parasite pressure is only evident in some immune gene categories.

HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis

The paper analyzes drug-resistant Mtb genomes from HIV coinfected and HIV negative patients, finding that HIV coinfected patients have more low fitness rpoB variants in rifampicin-resistant strains.

A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

The paper identifies a new lineage of Mycobacterium tuberculosis complex, Lineage 8, found in the African Great Lakes region, and shows its evolutionary relationship to known lineages.

The Evolution of Fluoroquinolone-Resistance in Mycobacterium tuberculosis is Modulated by the Genetic Background

This study shows that the genetic background of Mycobacterium tuberculosis significantly affects the evolution of fluoroquinolone resistance in both in vitro experiments and clinical isolates.

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis

The paper shows transition bias drives antibiotic resistance mutations in Mycobacterium tuberculosis, suggesting mutation supply, not selection, is the cause.

Whole genome sequencing for drug resistance profile prediction in Mycobacterium tuberculosis

This study uses whole genome sequencing to predict drug resistance profiles in M. tuberculosis isolates, achieving high sensitivity and specificity compared to phenotypic testing.

Reference Set of Mycobacterium tuberculosis Clinical Strains: A tool for research and product development

The paper introduces a reference set of 20 genetically characterized Mycobacterium tuberculosis clinical strains to enhance TB research by incorporating phylogenetic diversity beyond the commonly used lab strains.

A New Phylogenetic Framework for the Animal-adapted Mycobacterium tuberculosis Complex

This study analyzes 529 MTBC genomes to reveal the phylogenetic relationships and evolutionary history of animal-adapted MTBC ecotypes, identifying four clades and suggesting host shifts and demographic factors drive host tropism.