L. Gadhe

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

p53 amyloid pathology with cancer grades and p53 mutations

The paper shows p53 amyloid load correlates with cancer grades and shows both mutant and wild-type p53 form amyloids in cancer tissues.

Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions

The paper demonstrates that proteins and polypeptides can form liquid condensates under high intermolecular interaction conditions, showing that LLPS is a common state across diverse molecular structures.

Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids

This study investigates co-aggregation and cross-seeding between prolactin and galanin in rat lactotrophs, revealing a novel mechanism of heterologous amyloid formation with implications for functional and pathological amyloids.