S. Maiti

Evaluation of extraction solvents for untargeted metabolomics to decipher the dissolved organic matter of Antarctic cryoconite holes

This study evaluates solvent combinations for untargeted metabolomics to analyze dissolved organic matter in Antarctic cryoconite holes, finding that specific solvent mixtures enhance metabolite detection.

Electroencephalography for Radiation-Free Orientation Estimation of Directional Deep Brain Stimulation Leads

This paper develops and evaluates a radiation-free EEG framework to estimate directional DBS lead orientation in phantoms and human data, achieving sub-5 degree accuracy.

Single-molecule Mapping of Amyloid-β Oligomer Insertion intoLipid Bilayers

This study uses QSLIP to map amyloid-beta oligomer membrane insertion, finding toxicity correlates with amino-terminal penetration depth.

Serotonin Promotes Vesicular Association and Fusion by Modifying Lipid Bilayers

This study shows serotonin enhances vesicle association and fusion with lipid bilayers by altering their mechanical properties through water content changes.

The actin-associated protein Kaptin modulates F-actin barbed-end dynamics

This study identifies Kaptin as a novel actin regulator that inhibits nucleation and caps barbed ends, stabilizing and bundling actin filaments.

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

Liquid-liquid phase separation and aggregation of a globular folded protein SUMO1

This study shows that the globular protein SUMO1 undergoes liquid-liquid phase separation and transitions to solid aggregates under crowded conditions, challenging the assumption that only intrinsically disordered proteins can undergo LLPS.

A novel role of macrophage PIST protein in regulating Leishmania major infection

This study shows that macrophage PIST protein regulates Leishmania major infection by interacting with Beclin 1 and affecting parasite replication.

Probing the ligand binding specificity of FNBP4 WW domains and interaction with FH1 domain of FMN1

This study investigates the binding specificity of FNBP4 WW domains with the FH1 domain of FMN1 using surface plasmon resonance and ELISA, revealing that only the first WW domain is involved in the interaction.

Hsf1 and the molecular chaperone Hsp90 support a "rewiring stress response" leading to an adaptive cell size increase in chronic stress

The paper shows that chronic mild stress leads to adaptive cell size increase through Hsf1 and Hsp90, enhancing resilience to persistent stress.

Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions

The paper demonstrates that proteins and polypeptides can form liquid condensates under high intermolecular interaction conditions, showing that LLPS is a common state across diverse molecular structures.

Enzyme Aggregation and Fragmentation Induced by Catalysis Relevant Species

The paper examines enzyme aggregation and fragmentation during catalysis in three model enzymes, finding that specific substrates and ions induce structural changes without affecting catalytic activity.

Leishmania major formins are cytosolic actin bundler play an important role in cell physiology

This study identifies and characterizes two formins in Leishmania major, showing they bind and bundle actin, and are essential for parasite growth and morphology.

Receptor-independent membrane mediated pathways of serotonin action

This study shows serotonin can directly modulate membrane properties and cellular processes without acting through receptors.

Rational design of protein-specific folding modifiers

This paper designs a method to create protein-specific folding modifiers using xenonuclei, showing they can accelerate protein refolding by 33% under specific conditions.

Regulations of expressions of rat/human sulfotransferases (SULTs) by anti-cancer drug, nolatrexed and micronutrients.

This study examines how the anti-cancer drug nolatrexed and micronutrients like folic acid affect sulfotransferase (SULT) expressions in rats and HepG2 cells.

Energetics based epitope screening in SARS CoV-2 (COVID 19) spike glycoprotein by Immuno-informatic analysis aiming to a suitable vaccine development.

The paper screens epitopes in SARS-CoV-2 spike glycoprotein using immuno-informatic methods to identify potential vaccine targets based on energetics, IC50, and antigenicity.

Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones

This study identifies Fmn2 as a regulator of actin-microtubule crosstalk in neuronal growth cones, showing its role in chemotaxis and microtubule stabilization.

TUTase mediated site-directed access to clickable chromatin employing CRISPR-dCas9

This paper develops sgRNA-Click (sgR-CLK), a method to site-directly display synthetic molecules on chromatin using CRISPR-dCas9 and bioorthogonal click chemistry.

Specific cholesterol binding drives drastic structural alterations in Apolipoprotein A1

This study identifies specific cholesterol binding sites in ApoA1 that drive structural changes from closed to open conformations, revealing a mechanism for cholesterol sequestration.

Non Diaphanous Formin Delphilin Acts as a Barbed End Capping Protein

This study shows Delphilin, a formin with PDZ and FH domains, acts as a barbed end capping protein by inhibiting actin filament elongation and depolymerization.