A. Carvalho

The expression of integron arrays is shaped by the translation rate of cassettes

The paper shows that integron cassette expression depends on upstream translation rates, not distance to the Pc promoter.

Knowledge Innovation Ecosystem for the Promotion of User-Centre Health Innovations: Living Lab Methodology and Lessons Learned Through the Proposal of Standard Good Practices

This paper proposes standard good practices for Living Labs in health innovation, emphasizing marketing, stakeholder selection, engagement strategies, and sustainability.

Gibberellin and the miRNA156-targeted SlSBPs synergistically regulate tomato floral meristem activity and fruit patterning

This study shows that GA and miR156 regulate tomato floral meristem activity and fruit patterning through their interaction with SlSBPs, affecting fruit development traits.

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome

This study shows ghrelin improves cellular and organismal features of HGPS by promoting autophagy and clearing progerin, extending lifespan in a mouse model.

RavA-ViaA links Vibrio cholerae Cpx and Zra2 envelope stress to antibiotic response

This study shows that deletion of the ravA-viaA operon in Vibrio cholerae increases tolerance to aminoglycosides and affects polymyxin B sensitivity and vancomycin resistance by modulating Cpx and Zra2 two-component systems.

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.

Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen

This study identifies HscA as an effector protein from Aspergillus fumigatus that redirects phagosomes to the recycling expulsion pathway by anchoring p11, affecting susceptibility to invasive pulmonary aspergillosis.

miR319-targeted TCP4/LANCEOLATE directly regulates OVATE and auxin responses to modulate tomato gynoecium patterning and fruit morphology

This study identifies miR319-targeted TCP4/LA regulation of OVATE and auxin responses, revealing a molecular mechanism controlling tomato fruit morphology and gynoecium patterning.

A microfluidics-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer

This study develops a microfluidic method for label-free CTC isolation and cfDNA methylation analysis in lung cancer patients, showing improved diagnostic and prognostic potential through biomarker combinations.

Non-essential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress

The paper identifies tRNA and rRNA modification genes as critical factors affecting bacterial response to sub-MIC antibiotics from different families.

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

This study identifies conserved transcription factors and genes involved in gliotoxin protection in Aspergillus species through RNA-sequencing and deletion screening.

Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae

This study shows that DNA methylation deficiency in Vibrio cholerae increases tolerance to aminoglycosides by upregulating chaperonin genes that mitigate antibiotic-induced protein misfolding.

Aspergillus fumigatus acetate utilisation impacts virulence traits and pathogenicity

This paper investigates how acetate utilization by Aspergillus fumigatus affects virulence traits and pathogenicity, showing its role in secondary metabolite secretion, cell wall composition, and in vivo virulence.

Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis

This study shows that skin microbiota promotes IL-17A-producing RORγt+ ILCs, which drive inflammation in cutaneous leishmaniasis.

Microbiota and stress: a loop that impacts memory

This study shows that chronic stress alters gut microbiota in quails, and transferring this microbiota to germ-free hosts impairs memory and increases anxiety-like behavior.

Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes

This study shows that dynein-dynactin are essential for meiotic chromosome segregation in C. elegans spermatocytes, with a mutation causing aneuploidy and developmental defects.

Forward genetics in Wolbachia: Regulation of Wolbachia proliferation by the amplification and deletion of an addictive genomic island

This paper identifies two Wolbachia mutants with altered proliferation rates, showing that Octomom copy number affects proliferation, host lifespan, and antiviral protection.

Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections

This study shows that flotillin-dependent lipid rafts are essential for phagolysosomal function against fungal infections, with implications for human susceptibility to aspergillosis.

Paracoccin overexpression in Paracoccidioides brasiliensis reveals the influence of chitin hydrolysis on fungal virulence and host immune response

This study overexpresses paracoccin (PCN) in Paracoccidioides brasiliensis and finds that increased PCN levels enhance chitin hydrolysis, leading to smaller chitin particles that modulate host immune responses and increase fungal virulence.