Author

L. Toribio-Celestino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. San Millan· 6 shared J. DelaFuente· 4 shared R. Canton· 3 shared A. Alonso-del Valle· 2 shared A. Santos-Lopez· 2 shared C. Costas· 2 shared E. Vergara· 2 shared F. Trigo da Roza· 2 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersMicrobiology

A. San Millan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria

J. Sastre-Dominguez, J. DelaFuente, L. Toribio-Celestino, C. Herencias, P. Herrador-Gomez, C. Costas, M. Hernandez-Garcia, R. Canton, J. Rodriguez-Beltran, A. Santos-Lopez, A. San Millan

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

bioRxiv · Mar 1, 2024Microbiology

IDENTIFICATION OF PROMOTER ACTIVITY IN GENE-LESS CASSETTES FROM VIBRIONACEAE SUPERINTEGRONS

P. Blanco, A. Hipolito, L. Garcia-Pastor, F. Trigo da Roza, L. Toribio-Celestino, A. C. Ortega, E. Vergara, A. San Millan, J. A. Escudero

The paper identifies promoter activity in gene-less cassettes from Vibrio superintegrons, showing they enhance downstream cassette expression and confer antibiotic resistance.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

Chromosomal Integrons are Genetically and Functionally Isolated Units of Genomes

P. Blanco, F. Trigo da Roza, L. Toribio-Celestino, L. Garcia-Pastor, N. Caselli, F. Ojeda, B. Darracq, E. Vergara, A. San Millan, O. Skovgaard, D. Mazel, C. Loot, J. A. Escudero

The paper deletes a chromosomal integron in Vibrio cholerae and shows it has no detectable effect on physiology, proving its genetic and functional isolation.

bioRxiv · Nov 17, 2023Microbiology

The distribution of fitness effects of plasmid pOXA-48 in clinical enterobacteria

A. Fernandez-Calvet, L. Toribio-Celestino, A. Alonso-del Valle, J. Sastre-Dominguez, P. Valdes-Chiara, A. San Millan, J. DelaFuente

This study investigates the fitness effects of the plasmid pOXA-48 in clinical enterobacteria using CRISPR-Cas9 to cure plasmids, revealing mostly neutral effects with rare fitness costs or benefits.

bioRxiv · Jul 11, 2023 · PreprintMicrobiology

Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria

A. Alonso-del Valle, L. Toribio-Celestino, A. Quirant, C. Tardio Pi, J. DelaFuente, R. Canton, E. Rocha, C. Ubeda, R. Pena-Miller, A. San Millan

The paper investigates how antimicrobial resistance levels and conjugation permissiveness influence plasmid distribution in clinical enterobacteria, showing that specific bacterial clones stabilize plasmid spread.

bioRxiv · Apr 3, 2023Microbiology

Within-patient evolution of plasmid-mediated antimicrobial resistance

J. DelaFuente, L. Toribio-Celestino, A. Santos-Lopez, R. Leon-Sampedro, A. Aida Alonso-del Valle, C. Costas, M. Hernandez-Garcia, L. Cui, J. Rodriguez-Beltran, D. Bikard, R. Canton, A. San Millan

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

bioRxiv · May 31, 2022Evolutionary Biology