L. Gomes

Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species

This study analyzes 665 Mycobacterium kansasii complex strains to identify unique and shared genomic signatures, revealing lineage splits, virulence factors, and drug resistance mechanisms.

Extracellular prostaglandins E1 and E2 and inflammatory cytokines are regulated by the senescence program in potentially premalignant oral keratinocytes

This study shows that senescence in premalignant oral keratinocytes increases extracellular prostaglandins E1 and E2 and inflammatory cytokines, which may promote progression to oral SCC through paracrine signaling.

Development and validation of an assay for detection of Japanese Encephalitis virus specific antibody responses

This paper develops an ELISA to detect JEV-specific antibodies that do not cross-react with DENV and finds that JEV seropositivity is associated with severe dengue.

Phenotype and functionality of follicular helper T cells in patients with acute dengue infection

This study examines the phenotype and functionality of follicular helper T cells (Tfh) in dengue patients, finding their expansion correlates with severe disease and antibody responses, but not with protective immunity.

Role of NS1 antibodies in the pathogenesis of acute dengue infection

This study examines NS1 antibody responses in dengue patients, finding higher titres and distinct epitope targeting in severe cases, suggesting potential for disease prediction and vaccine design.

Quantification of dengue virus specific T cell responses and correlation with viral load and clinical disease severity in acute dengue infection

This study quantifies dengue virus-specific T cell responses in acute dengue infection and finds they correlate with clinical severity and viraemia resolution.