De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
H. Zhang, Q. Yu, N. Santana-Codina, C. Poupault, C. Campos, X. Qin, A. Padhye, N. Sindoni, M. Kuljanin, J. Wang, M. J. Dorman, A. J. Aguirre, S. K. Dougan, K. A. Sarosiek, J. D. Mancias
This study identifies that combining DHODH inhibition with BCL-XL targeting synergistically induces apoptosis in pancreatic cancer, offering a new combination therapy strategy.
bioRxiv · May 17, 2024 · PreprintCancer Biology