Author

L. Guruprasad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Tabor· 1 shared A. Zhyvoloup· 1 shared C. Eyers· 1 shared D. Byrne· 1 shared E. Chan· 1 shared F. Bellany· 1 shared I. Gout· 1 shared J. Bakovic· 1 shared

Activity by Year

2018-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. Tabor

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2 papers

Recent·Most cited

Dynamic conformational states of apo and cabozantinib bound TAM kinases to differentiate active-inactive kinetic models

L. Guruprasad, K. R. S. N. GATTA

This study uses molecular dynamics simulations to analyze dynamic conformational states of TAM kinases with and without cabozantinib, revealing structural changes that differentiate active and inactive states.

bioRxiv · Apr 21, 2021Biophysics

Covalent Aurora A regulation by the metabolic integrator coenzyme A

Y. Tsuchiya, D. Byrne, S. Burgess, J. Bormann, J. Bakovic, Y. Huang, A. Zhyvoloup, S. Peak-Chew, T. Tran, F. Bellany, A. Tabor, E. Chan, L. Guruprasad, O. Garifulin, V. Filonenko, , I. Gout

This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.

bioRxiv · Nov 14, 2018Biochemistry