Author

S. Peak-Chew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. G. Murzin· 1 shared A. Tabor· 1 shared A. Zhyvoloup· 1 shared B. Ghetti· 1 shared C. Eyers· 1 shared C. Franco· 1 shared C. Latimer· 1 shared C. Qi· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. G. Murzin

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Author profile →

3 papers

Recent·Most cited

Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W

C. Qi, S. Lovestam, A. G. Murzin, S. Peak-Chew, C. Franco, M. Bogdani, C. Latimer, J. R. Murrell, P. W. Cullinane, Z. Jaunmuktane, T. D. Bird, B. Ghetti, S. H. W. Scheres, M. Goedert

The paper determines the structures of tau filaments in individuals with MAPT mutations V337M and R406W using cryo-EM, finding the Alzheimer fold in all cases and a new triple filament assembly.

bioRxiv · Apr 29, 2024 · PreprintBiophysics

Ebselen attenuates mycobacterial virulence through inhibition of ESX-1 secretion

M. M. Osman, M. L. Pinckert, S. Peak-Chew, M. A. Troll, W. H. Conrad, L. Ramakrishnan

This paper shows ebselen inhibits ESX-1 secretion in M. marinum and M. tuberculosis, reducing virulence and intracellular growth.

bioRxiv · Dec 13, 2021 · PreprintMicrobiology

Covalent Aurora A regulation by the metabolic integrator coenzyme A

Y. Tsuchiya, D. Byrne, S. Burgess, J. Bormann, J. Bakovic, Y. Huang, A. Zhyvoloup, S. Peak-Chew, T. Tran, F. Bellany, A. Tabor, E. Chan, L. Guruprasad, O. Garifulin, V. Filonenko, , I. Gout

This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.

bioRxiv · Nov 14, 2018Biochemistry