Author

L. H. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

M. Zhang· 2 shared Q. Yan· 2 shared A. Aoshima· 1 shared A. Arnal-Estape· 1 shared A. Balabaki· 1 shared C. J. Booth· 1 shared D. Nguyen· 1 shared D. Rimm· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

M. Zhang

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

Q. Yan, J. F.-Y. Chen, W. Cai, H. Chen, E. Wingrove, S. Kurley, L. H. Chan, M. Zhang, A. Arnal-Estape, M. Zhao, A. Balabaki, W. Li, X. Yu, Y. Dou, Y. Liu, , D. Nguyen

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

bioRxiv · Mar 30, 2022 · PreprintCancer Biology

CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

M. Zhang, Z. Liu, K. Aoshima, Y. Zhang, Y. An, A. Aoshima, L. H. Chan, S. Lang, H. Sun, Z. Tang, S. Rutter, C. J. Booth, V. Bossuyt, X. Chen, J. Morrow, , Q. Yan

This study identifies CECR2 as a driver of breast cancer metastasis by suppressing macrophage inflammatory responses, offering a therapeutic target for metastatic disease.

bioRxiv · Sep 10, 2020Cancer Biology