Author

L. Hardy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

X. Charpentier· 2 shared A. B. Dalia· 1 shared A. Hamacher-Brady· 1 shared A. Singh· 1 shared B. Coupat-Goutaland· 1 shared C. J. Rousseau· 1 shared D. A. East· 1 shared D. Faccenda· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

X. Charpentier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Two D-loop resolution systems enable natural genetic transformation in bacteria

L. Hardy, V. Morales, C. J. Rousseau, M. Berge, J. Plantade, F. Mazzamurro, T. N. Dalia, A. B. Dalia, E. P. C. Rocha, X. Charpentier, P. Polard

This study identifies two D-loop resolution systems in bacteria, YraN/ComM and CoiA/RadA, that work together to process the transformation D-loop during natural genetic transformation.

bioRxiv · Feb 6, 2024Microbiology

Persistent DNA damage promotes microglial dysfunction in Ataxia-telangiectasia

J. Bourseguin, W. Cheng, E. Talbot, L. Hardy, S. V. Khoronenkova

This study shows that DNA damage in Ataxia-telangiectasia leads to microglial dysfunction via the RELB/p52 pathway, causing excessive neurite phagocytosis and contributing to neurodegeneration.

bioRxiv · Jun 2, 2021Cell Biology

Transposon-insertion sequencing in a clinical isolate of Legionella pneumophila identifies essential genes and determinants of natural transformation

L. Hardy, P.-A. Juan, B. Coupat-Goutaland, X. Charpentier

bioRxiv · Oct 1, 2020Microbiology

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response

R. Desai, D. A. East, L. Hardy, M. Rigon, D. Faccenda, M. S. Alvarex, A. Singh, M. Mainenti, L. K. Hussey, R. Bentham, G. Szabadkai, V. Zappulli, G. Dhoot, L. E. Romano, X. Dong, , M. Campanella

The paper shows mitochondria form contact sites with the nucleus to facilitate a pro-survival retrograde response by stabilizing transcription factors like NF-kB.

bioRxiv · May 7, 2020 · PreprintCell Biology