Mitochondria drive microglial NRLP3 inflammasome activation via TSPO
A. Singh, M. Rigon, M. Caldeira, D. Faccenda, D. Xia, J. Lopez-Tremoleda, Z. Falah Hassan Al-Khateeb, T. Guo, R. Abeti, P. Giunti, M. Campanella
This study shows TSPO on mitochondria promotes microglial inflammasome activation by stabilizing NLR proteins, inhibiting mitophagy, and enhancing pro-inflammatory gene expression, leading to excitotoxicity.
bioRxiv · Mar 18, 2024 · PreprintCell Biology