XIAP-mediated targeting of endolysosomes to stressed mitochondria occurs in a switch-like, global manner and results in autophagy-independent, sub-organelle level mitochondrial degradation
T. S. Wang, I. Coppens, N. R. Brady, A. Hamacher-Brady
The paper shows XIAP mediates rapid, global endolysosome targeting to stressed mitochondria, leading to sub-organelle degradation independent of autophagy.
bioRxiv · Apr 23, 2023 · PreprintCell Biology