Author

L. Harker-Kirschneck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Research Focus:development & morphogenesis· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. Saric· 5 shared B. Baum· 5 shared F. Hurtig· 3 shared A. Arashiro Pulschen· 2 shared C. Vanhille Campos· 2 shared G. Tarrason Risa· 2 shared R. Henriques· 2 shared S. Culley· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersBiophysics

A. Saric

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Modelling Membrane Reshaping by Staged Polymerization of ESCRT-III Filaments

X. Jiang, L. Harker-Kirschneck, C. Vanhille Campos, A.-K. Pfitzner, E. Lominadze, A. Roux, B. Baum, A. Saric

The paper models how ESCRT-III filaments reshape membranes through staged polymerization and depolymerization, identifying mechanical conditions for membrane deformation and scission.

bioRxiv · Oct 3, 2022Biophysics

The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division

F. Hurtig, T. C. Q. Burgers, A. Cezanne, X. Jiang, F. N. Mol, J. Traparic, G. Tarrason Risa, A. Arashiro Pulschen, L. Harker-Kirschneck, A. Saric, R. Vlijm, B. Baum

The paper uses super-resolution microscopy and computational modeling to show how CdvB/CdvB1/CdvB2 proteins form a patterned composite ESCRT-III division ring that disassembles stepwise to drive archaeal cell division.

bioRxiv · Sep 16, 2022Cell Biology

Physical mechanisms of ESCRT-III-driven cell division in archaea

L. Harker-Kirschneck, A. E. Hafner, T. Yao, A. A. Pulschen, F. Hurtig, C. Vanhille Campos, D. Hryniuk, S. Culley, R. Henriques, B. Baum, A. Saric

The paper develops a physical model to explain how ESCRT-III filaments drive cell division in archaea, showing that active geometry changes and disassembly are sufficient for efficient splitting.

bioRxiv · Mar 23, 2021 · PreprintBiophysics

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

G. Tarrason Risa, F. Hurtig, S. Bray, A. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D. R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. L. Kilkenny, , B. Baum

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

bioRxiv · Sep 18, 2019 · PreprintCell Biology

Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico

L. Harker-Kirschneck, B. Baum, A. Saric

This paper develops a computational model to simulate ESCRT-III filament dynamics and shows how changes in filament geometry drive membrane remodeling and scission.

bioRxiv · Sep 10, 2019 · PreprintBiophysics