T. Yao

Catabolic pathway acquisition by soil pseudomonads readily enables growth with salicyl alcohol but does not affect colonization of Populus roots

The paper transfers a catabolic pathway for salicyl alcohol in Pseudomonas soil isolates, showing it enables rapid catabolism but does not confer a fitness advantage in rhizosphere competition.

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFkB signaling

This study shows STING activates NFkB signaling via HOIP-mediated M1 ubiquitin chains on Golgi membranes, independent of LC3B lipidation.

Co-infecting phages impede each other's entry into the cell

The paper shows co-infecting phages impede each other's entry into cells, revealing MOI-dependent host physiological changes that affect infection outcomes.

Interindividual Diversity of Human Gut Mucin-Degrading Microbial Consortia

The paper examines interindividual differences in human gut microbial communities capable of degrading mucin, finding taxonomic variation but functional redundancy in mucin metabolism.

Functional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination

This study functionally characterizes candidate sex determination genes in Salix purpurea using Arabidopsis, supporting ARR17 and GATA15 as master regulators and identifying downstream transcription factors.

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85beta/AP-2-mediated endocytosis

The paper identifies a non-catalytic role of PI3K in cell migration via p85beta/AP-2-mediated endocytosis, independent of its catalytic activity.

SUBTLE DIFFERENCES IN FINE POLYSACCHARIDE STRUCTURES GOVERN SELECTION AND SUCCESSION OF HUMAN GUT MICROBIOTA

The paper investigates how subtle differences in polysaccharide structures influence microbial community assembly and metabolic responses in human gut microbiota using in vitro fermentation and multi-omics analysis.

Plant-based biosensors for detecting CRISPR-mediated genome engineering

This study develops plant-based biosensors to detect CRISPR/Cas tools in real-time, demonstrating their effectiveness in detecting various CRISPR functions in multiple plant species.

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans

This study shows autophagosomes fuse with phagosomes to aid in the degradation of apoptotic cells in C. elegans, revealing a novel role for autophagosomes in phagosome maturation.

The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota

This study shows that xanthan gum, a common food additive, promotes the adaptation of the human gut microbiota by enabling a novel degradation pathway in an uncultured Ruminococcaceae bacterium and facilitating cross-feeding by Bacteroides species.

Fine carbohydrate structure governs the structure and function of human gut microbiota independently of variation in glycosyl residue composition

This study shows that fine carbohydrate linkage structure, not sugar composition, drives gut microbiota composition and function across individuals.

Physical mechanisms of ESCRT-III-driven cell division in archaea

The paper develops a physical model to explain how ESCRT-III filaments drive cell division in archaea, showing that active geometry changes and disassembly are sufficient for efficient splitting.

Carbohydrate complexity structures stable diversity in gut-derived microbial consortia under high dilution pressure

This study shows that complex carbohydrates sustain microbial diversity better than simpler ones under dilution pressure, with structural complexity shaping community composition more than metabolic interactions.

High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.

Microarray screening of differentially expressed genes after up-regulating miR-205 or down-regulating miR-141 in cervical cancer cells

The paper uses microarray analysis to identify differentially expressed genes in cervical cancer cells after modulating miR-205 and miR-141, revealing potential pathways and gene regulation.

High-affinity free ubiquitin sensors as quantitative probes of ubiquitin homeostasis and deubiquitination

The paper develops high-affinity fluorescent sensors to quantify free ubiquitin and monitor deubiquitination in cells.

Polycomb Cbx2 Condensates Assemble through Phase Separation

This study shows that Cbx2 forms condensates via phase separation, which may organize PcG-bound chromatin.

Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner

This study shows that thermoneutrality causes skeletal muscle myopathy through brown adipose tissue via IRF4 and myostatin mechanisms.