Author

M. L. Kilkenny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

L. Pellegrini· 3 shared N. J. Rzechorzek· 2 shared A. Arashiro Pulschen· 1 shared A. Guppy· 1 shared A. Hafner· 1 shared A. P. Snijders· 1 shared A. Saric· 1 shared A.-C. Lindas· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiophysics

L. Pellegrini

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with Pol α - Primase

M. L. Kilkenny, C. E. Veale, A. Guppy, S. W. Hardwick, D. Y. Chirgadze, N. J. Rzechorzek, J. D. Maman, L. Pellegrini

This study reports the cryoEM structure of the SARS-CoV-2 nsp1-primosome complex, revealing how nsp1 interacts with the DNA polymerase-primase complex to disrupt immune responses.

bioRxiv · Jun 17, 2021 · PreprintBiophysics

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

G. Tarrason Risa, F. Hurtig, S. Bray, A. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D. R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. L. Kilkenny, , B. Baum

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

bioRxiv · Sep 18, 2019 · PreprintCell Biology

Structural basis for inhibition of human primase by arabinofuranosyl nucleoside analogues Fludarabine and Vidarabine

S. Holzer, N. J. Rzechorzek, I. R. Short, M. Jenkyn-Bedford, L. Pellegrini, M. L. Kilkenny

This study provides a structural basis for how Fludarabine and Vidarabine inhibit human primase, suggesting ways to improve their therapeutic efficacy and reduce toxicity.

bioRxiv · Apr 11, 2019Biochemistry