MYC promotes immune-suppression in TNBC via inhibition of IFN signaling
D. Zimmerli, C. S. Brambillasca, F. Talens, J. Bhin, A. Bhattacharya, S. E. P. Joosten, A. Moises da Silva, M. D. Wellenstein, K. Kersten, M. de Boo, M. Roorda, L. Henneman, R. de Bruijn, S. Annunziato, E. van der Burg, , J. Jonkers
This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.
bioRxiv · Feb 24, 2021 · PreprintCancer Biology