Author

J. Jonkers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 11 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Organism:human· 6 Organism:mouse· 6 Assay:bulk RNA-seq· 5 Research Focus:cancer & tumor microenvironment· 5 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Assay:DNA methylation· 4

Frequent Co-Authors

S. Rottenberg· 4 shared C. Lieftink· 3 shared E. Gogola· 3 shared J. Bhin· 3 shared M. Paes Dias· 3 shared R. de Bruijn· 3 shared S. Annunziato· 3 shared A. Duarte· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

S. Rottenberg

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12 papers

Recent·Most cited

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

B. Inanc, Q. Fang, J. F. Andrews, X. Zeng, J. Clark, J. Li, N. B. Dey, M. Ibrahim, P. Sykora, Z. Yu, A. Braganza, M. Verheij, J. Jonkers, N. A. Yates, C. Vens, R. W. Sobol

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

Chemotherapy-treated breast cancer cells activate the Wnt signaling pathway to enter a diapause-DTP state.

F. Lluis, Y. Ellaithy, W. A. Abreu de Oliveira, A. Pabba, A. Qualizza, F. Richard, P. Athanasouli, C. R. Luci, W. De Wispelaere, L. Mourao, S. Hamer, S. Moens, A. De Jaime-Soguero, M. Francesca Baietti, S. J. Hutten, , D. Annibali

This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

D. Dibitetto, M. Liptay, F. Vivalda, E. Gogola, H. Dogan, M. G. Fernandez, A. Duarte, J. A. Schmid, S. T. Durant, J. V. Forment, I. Klebic, M. Siffert, R. de Brujin, A. N. Kousholt, N. A. Marti, , S. Rottenberg

This study identifies H2AX's role in promoting replication fork degradation and chemosensitivity in BRCA-deficient tumours, independent of its classical DNA damage signalling function.

bioRxiv · May 22, 2023Cancer Biology

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

J. M. Houthuijzen, R. de Bruijn, E. van der Burg, A. P. Drenth, E. Wientjens, T. Filipovic, E. Bullock, C. S. Brambillasca, M. Nieuwland, I. de Rink, F. van Diepen, S. Klarenbeek, R. Kerkhoven, V. Brunton, C. L. G. J. Scheele, , J. Jonkers

The paper identifies CD26-negative and CD26-positive tissue-resident fibroblasts as sources of distinct CAF subpopulations in breast cancer through single-cell transcriptomics and functional assays.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

J. Bhin, M. Paes Dias, E. Gogola, F. Rolfs, S. R. Piersma, R. de Bruijn, J. de Ruiter, B. van den Broek, A. Duarte, W. Sol, I. van der Heijden, L. Bakker, T. S. Kaiponen, C. Lieftink, B. Morris, , J. Jonkers

bioRxiv · Sep 7, 2022Cancer Biology

Hyperactive WNT/CTNNB1 signaling induces a competing cell proliferation and epidermal differentiation response in the mouse mammary epithelium

L. Mourao, A. L. Zeeman, K. E. Wiese, A. Bongaarts, L. L. Oudejans, I. Mora Martinez, Y. B. C. van de Grift, J. Jonkers, R. van Amerongen

This study investigates the effects of hyperactive WNT/CTNNB1 signaling in mouse mammary epithelium, showing it induces competing proliferation and differentiation responses depending on signaling levels.

bioRxiv · Jun 22, 2021 · PreprintCancer Biology

Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps

M. Paes Dias, V. Tripathi, I. v. d. Heijden, K. Cong, E.-M. Manolika, J. Bhin, E. Gogola, P. Galanos, S. Annunziato, C. Lieftink, M. Andujar-Sanchez, S. Chakrabarty, G. C. M. Smith, M. v. d. Ven, R. L. Beijersbergen, , J. Jonkers

This study identifies loss of LIG3 as a factor that reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by increasing ssDNA gaps.

bioRxiv · Mar 24, 2021 · PreprintCancer Biology

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

D. Zimmerli, C. S. Brambillasca, F. Talens, J. Bhin, A. Bhattacharya, S. E. P. Joosten, A. Moises da Silva, M. D. Wellenstein, K. Kersten, M. de Boo, M. Roorda, L. Henneman, R. de Bruijn, S. Annunziato, E. van der Burg, , J. Jonkers

This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology

SMARCAD1 Mediated Active Replication Fork Stability Maintains Genome Integrity

C. Lo, M. van Toorn, V. Gaggioli, M. Paes Dias, Y. Zhu, E. Maria Manolika, W. Zhao, M. van der Does, C. Mukherjee, J. Souto Goncalves, M. van Royen, P. French, J. Demmers, I. Smal, H. Lans, , N. Taneja

This study identifies SMARCAD1 as a critical factor for replication fork stability, showing its role in preventing genome instability and enhancing resistance to replication poisons.

bioRxiv · Oct 5, 2020Cell Biology

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

K. Cong, A. N. Kousholt, M. Peng, N. J. Panzarino, W. T. C. Lee, S. Nayak, J. Krais, J. Calvo, M. Bere, E. Rothenberg, N. Johnson, J. Jonkers, S. Cantor

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

bioRxiv · Sep 25, 2019Cancer Biology

Glucocorticoids regulate cancer cell dormancy

S. Prekovic, K. Schuurman, A. Gonzalez Manjon, M. Buijs, I. Mayayo Peralta, M. D. Wellenstein, S. Yavuz, A. Barrera, K. Monkhorst, A. Huber, B. Morris, C. Lieftink, J. Silva, B. Györffy, L. Hoekman, , W. Zwart

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.

bioRxiv · Sep 4, 2019 · PreprintCancer Biology

Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors

M. Barazas, A. Gasparini, Y. Huang, A. Kucukosmanoglu, S. Annunziato, P. Bouwman, W. Sol, A. Kersbergen, N. Proost, M. van de Ven, J. Jonkers, G. Borst, S. Rottenberg

This study identifies radiotherapy as a therapeutic target for BRCA1-deficient tumors that have developed resistance to PARP inhibitors through 53BP1 pathway inactivation.

bioRxiv · Jul 17, 2018Cancer Biology