K. Kersten

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.

This study shows that uptake of tumor-derived microparticles by macrophages in the early metastatic lung leads to metabolic reprogramming and altered function.

Myeloid mechano-metabolic programming restricts anti-tumor immunity

This study shows that fibrotic tumor microenvironments impair anti-tumor immunity through myeloid cell-driven metabolic changes that hinder CD8+ T cell function.

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.