Author

L. I. Crouch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. N. Bolam· 3 shared A. Basle· 2 shared D. I. Spencer· 2 shared P. A. Urbanowicz· 2 shared B. Pilgaard· 1 shared C. A. Lamb· 1 shared C. J. Stewart· 1 shared C. R. Bakshani· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

D. N. Bolam

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Author profile →

3 papers

Recent·Most cited

Carbohydrate-active enzymes from Akkermansia muciniphila breakdown mucin O-glycans to completion

L. I. Crouch, C. R. Bakshani, T. O. Ojuri, B. Pilgaard, J. Holck, R. McInnes, M. Zakhour, M. Kerouedan, E. Newton, D. N. Bolam, R. P. Kozak, S. Cakaj

This study characterizes carbohydrate-active enzymes from Akkermansia muciniphila to show they synergistically degrade mucin O-glycans to the core GalNAc.

bioRxiv · Mar 27, 2024 · PreprintBiochemistry

Plant N-glycan breakdown by human gut Bacteroides

L. I. Crouch, P. A. Urbanowicz, A. Basle, Z.-P. Cai, L. Liu, J. Voglmeir, J. M. Melo Diaz, S. T. Benedict, D. I. Spencer, D. N. Bolam

The paper identifies a pathway for breaking down plant N-glycans in gut Bacteroides and characterizes enzymes involved, with potential applications in allergen modification and therapeutic protein stability.

bioRxiv · Apr 7, 2022Biochemistry

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

L. I. Crouch, D. N. Bolam, A. Basle, C. J. Stewart, M. Wuhrer, R. J. Linhardt, M. V. Liberato, C. A. Lamb, F. Zhang, K. Cooke, M. Doona, S. Needham, R. R. Brady, J. E. Berrington, K. Madunic, , R. Glowacki

The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.

bioRxiv · Nov 9, 2019Biochemistry