R. J. Linhardt

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D

This study identifies the N-terminal domain (NTD) of p53 as the major binding site for Cyclophilin D, revealing dynamic electrostatic interactions and a minimal binding region for mPTP regulation.

Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

This study shows rhamnan sulfate reduces atherosclerosis and vascular inflammation in ApoE-/- mice by enhancing endothelial barrier function and inhibiting NF-κB pathway activation.

Golgi structural defect impairs glycosaminoglycan synthesis, sulfation, and secretion

This study shows that disrupting Golgi structure by knocking out GRASP55 and GRASP65 alters glycosaminoglycan synthesis, sulfation, and secretion.

Circadian Control of Heparan Sulfate Levels Times Phagocytosis of Amyloid Beta Aggregates

This study shows that circadian rhythms control heparan sulfate levels, which regulate phagocytosis of amyloid-beta aggregates in a mouse model of Alzheimer's disease.

Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives

This study evaluates the antiviral activity of heparin and enoxaparin derivatives against SARS-CoV-2 by testing their ability to neutralize pseudotyped virus particles.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.