Author

L. J. Handlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

G. Dai· 2 shared A. Moutal· 1 shared E. N. Lessie· 1 shared K. S. McCommis· 1 shared L. Salih· 1 shared N. Dumaire· 1 shared N. L. Macchi· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

G. Dai

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Author profile →

2 papers

Recent·Most cited

Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons

L. J. Handlin, N. L. Macchi, N. Dumaire, L. Salih, E. N. Lessie, K. S. McCommis, A. Moutal, G. Dai

The paper shows that lipid nanodomains modulate HCN channels in DRG neurons, affecting pain signaling and neuronal firing.

bioRxiv · Sep 2, 2023Biophysics

Direct Regulation of the Voltage Sensor of HCN Channels by Membrane Lipid Compartmentalization

L. J. Handlin, G. Dai

The paper investigates how membrane lipid domains affect the voltage sensor of HCN channels using FLIM and FRET, finding that lipid compartmentalization influences channel activity and contributes to disease.

bioRxiv · Jun 15, 2023Physiology