K. S. McCommis

Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons

The paper shows that lipid nanodomains modulate HCN channels in DRG neurons, affecting pain signaling and neuronal firing.

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult in mice

This study shows that loss of both MPC and ALT2 increases susceptibility to oxidative stress and worsens liver injury in mice, while ALT2 induction reduces APAP toxicity.

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in Mice

This study shows that increasing MBOAT7 expression in mice with NASH does not significantly improve liver histology, likely due to low arachidonoyl-CoA substrate levels.

MSDC-0602K, A Novel Insulin-Sensitizer Improves Insulinemia and Fatty Liver Disease Alone and in Addition to Liraglutide in Mice

This study evaluates a novel insulin-sensitizer MSDC-0602K in combination with Liraglutide, showing improved glycemia and liver disease in diabetic and NASH mouse models.

Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism

This study shows that a ketogenic diet prevents heart failure in mice with defective mitochondrial pyruvate metabolism by reversing cardiac remodeling and dysfunction.

NADPH and glutathione redox link TCA cycle activity to endoplasmic reticulum stress

The paper shows that TCA cycle activity influences ER stress via NADPH and glutathione redox metabolism in mouse hepatocytes.