Author

L. J. McClelland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

S. R. Sprang· 2 shared A. Mansilla· 1 shared A. Wohlkonig· 1 shared C. J. Thomas· 1 shared C. Yates-Hansen· 1 shared D. Munoz-Reyes· 1 shared G. G. Tall· 1 shared J. Garcia-Nafria· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

S. R. Sprang

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Author profile →

2 papers

Recent·Most cited

The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A

D. Munoz-Reyes, L. J. McClelland, S. Arroyo-Urea, S. Sanchez-Yepes, J. Sabin, S. Perez-Suarez, M. Menendez, A. Mansilla, J. Garcia-Nafria, S. R. Sprang, M. J. Sanchez-Barrena

This study investigates how NCS-1 regulates Ric-8A's activity and G-protein interaction through structural and functional analyses.

bioRxiv · Dec 9, 2022Biochemistry

Crystal and cryo-EM structures of the cytosolic G protein alpha chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

L. J. McClelland, K. Zhang, T.-C. Mou, J. Johnston, C. Yates-Hansen, S. li, C. J. Thomas, T. I. Doukov, S. Triest, A. Wohlkonig, G. G. Tall, J. Steyaert, W. Chiu, S. R. Sprang

This study reports the crystal and cryo-EM structures of Ric-8A bound to Gαi1, revealing its mechanism of GTP exchange and chaperone activity through structural interactions.

bioRxiv · Jan 4, 2020 · PreprintBiochemistry