Crystal and cryo-EM structures of the cytosolic G protein alpha chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
L. J. McClelland, K. Zhang, T.-C. Mou, J. Johnston, C. Yates-Hansen, S. li, C. J. Thomas, T. I. Doukov, S. Triest, A. Wohlkonig, G. G. Tall, J. Steyaert, W. Chiu, S. R. Sprang
This study reports the crystal and cryo-EM structures of Ric-8A bound to Gαi1, revealing its mechanism of GTP exchange and chaperone activity through structural interactions.
bioRxiv · Jan 4, 2020 · PreprintBiochemistry