Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
Y. Pang, Q. Li, Z. Sergi, G. Yu, X. Sang, O. Kim, H. Wang, A. Ranjan, M. Merchant, B. Oudit, R. W. Robey, F. Soheilian, B. Tran, F. J. Nunez, M. Zhang, , J. Wu
This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.
bioRxiv · Jun 29, 2023Cancer Biology
E. J. Chory, M. Wang, M. Ceribelli, A. M. Michalowska, S. Golas, E. Beck, C. Klumpp-Thomas, L. Chen, C. McKnight, Z. Itkin, S. Divakaran, J. Bradner, J. Khan, B. E. Gryder, C. J. Thomas, B. Z. Stanton
This paper identifies synergistic drug combinations in AML using high-throughput methods and open-source tools, revealing synergies affecting histone H3 lysine-27 modification.
SLAS Discovery · Jun 1, 2023Peer-reviewedCancer Biology
Y. Yang, T. Oellerich, P. Chen, A. Bolomsky, M. Ceribelli, B. Haupl, G. W. Wright, J. D. Phelan, D. W. Huang, J. W. Lord, C. K. Van Winkle, X. Yu, J. Wisnieski, J. Q. Wang, F. A. Tosto, , R. M. Young
This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.
bioRxiv · Nov 28, 2021Cancer Biology
M. J. Evans, K. Kay, C. Proctor, C. J. Thomas, J. W. Malcom
The paper links mountaintop removal mining to water quality degradation in streams critical for imperiled species using satellite data and water quality monitoring.
bioRxiv · Sep 14, 2020 · PreprintEcology
A. Luengo, Z. Li, D. Y. Gui, L. B. Sullivan, M. Zagorulya, B. T. Do, R. Ferriera, A. Naamati, A. Ali, C. A. Lewis, C. J. Thomas, S. Spranger, N. J. Matheson, M. G. Vander Heiden
The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.
bioRxiv · Jun 8, 2020Biochemistry
D. Dersh, J. D. Phelan, M. E. Gumina, B. Wang, J. H. Arbuckle, J. Holly, R. J. Kishton, T. E. Markowitz, M. O. Seedhom, N. Fridlyand, G. W. Wright, D. W. Huang, M. Ceribelli, C. J. Thomas, J. B. Lack, , J. W. Yewdell
The paper identifies genes modulating MHC-I and MHC-II expression in lymphomas, revealing potential targets for immunosurveillance manipulation.
bioRxiv · Mar 13, 2020Cancer Biology
S. L. Lewandowski, R. L. Cardone, H. R. Foster, T. Ho, E. Potapenko, C. Poudel, H. R. VanDeusen, T. C. Alves, X. Zhao, M. E. Capozzi, I. Jahan, C. S. Nunemaker, J. E. Campbell, C. J. Thomas, R. G. Kibbey, M. J. Merrins
This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.
bioRxiv · Jan 15, 2020Cell Biology
L. J. McClelland, K. Zhang, T.-C. Mou, J. Johnston, C. Yates-Hansen, S. li, C. J. Thomas, T. I. Doukov, S. Triest, A. Wohlkonig, G. G. Tall, J. Steyaert, W. Chiu, S. R. Sprang
This study reports the crystal and cryo-EM structures of Ric-8A bound to Gαi1, revealing its mechanism of GTP exchange and chaperone activity through structural interactions.
bioRxiv · Jan 4, 2020 · PreprintBiochemistry
J. D. Guss, E. Taylor, Z. Rouse, S. Roubert, C. H. Higgins, C. J. Thomas, S. Baker, D. Vashishth, E. Donnelly, M. K. Shea, S. L. Booth, R. L. Bicalho, C. Hernandez
This study links microbiome-induced changes in vitamin K synthesis to reduced bone strength in mice through metagenomic analysis.
bioRxiv · Mar 1, 2019Bioengineering