B-cell specific expression of the murine Myd88L252P mutation correlates with the establishment of an immunosuppressive microenvironnement in Waldenstrom macroglobulinemia lymphoplasmacytic lymphoma
Q. LEMASSON, O. TETEAU, M. CHABAUD, L. JEANSON, J. FEUILLARD, C. VINCENT-FABERT
This study shows that B-cell specific Myd88L252P mutation in mice leads to an immunosuppressive microenvironment in Waldenstrom macroglobulinemia, promoting T-cell exhaustion and disease progression.
bioRxiv · Sep 28, 2023 · PreprintImmunology