Author

L. K. Heisler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Roumane· 1 shared E. De Frutos Gonzalez· 1 shared E. J. McKay· 1 shared G. D. Mcilroy· 1 shared I. Luijten· 1 shared J. J. Rochford· 1 shared M. G. Kolonin· 1 shared N. Sommer· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Roumane

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2 papers

Recent·Most cited

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström Syndrome

E. J. McKay, I. Luijten, X. Weng, P. B. Martinez de Morentin, E. De Frutos Gonzalez, Z. Gao, M. G. Kolonin, L. K. Heisler, R. K. Semple

This study shows that deleting Alms1 in mesenchymal cells in mice causes metabolic issues similar to Alström Syndrome, including insulin resistance and fatty liver.

bioRxiv · Oct 12, 2023Physiology

GLP-1 Receptor Agonist Improves Metabolic Disease in a Pre-clinical Model of Lipodystrophy

A. Roumane, G. D. Mcilroy, N. Sommer, W. Han, L. K. Heisler, J. J. Rochford

This study shows that liraglutide, a GLP-1R agonist, improves metabolic disease in seipin knockout mice, a model of lipodystrophy, by enhancing insulin secretion and reducing liver fibrosis.

bioRxiv · Sep 1, 2023Pharmacology & Toxicology