Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice
R. Salzer, J. J. Clark, M. Vaysburd, V. T. Chang, A. Albecka, L. Kiss, P. Sharma, A. Gonzalez Llamazares, A. Kipar, J. A. Hiscox, A. Owen, A. R. Aricescu, J. P. Stewart, L. C. James, J. Lowe
This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.
bioRxiv · May 18, 2021Immunology