Author

V. T. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Carr· 1 shared A. Albecka· 1 shared A. E. Lindsay· 1 shared A. Gonzalez Llamazares· 1 shared A. Kipar· 1 shared A. M. Santos· 1 shared A. Owen· 1 shared A. Ponjavic· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

A. A. Carr

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2 papers

Recent·Most cited

Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice

R. Salzer, J. J. Clark, M. Vaysburd, V. T. Chang, A. Albecka, L. Kiss, P. Sharma, A. Gonzalez Llamazares, A. Kipar, J. A. Hiscox, A. Owen, A. R. Aricescu, J. P. Stewart, L. C. James, J. Lowe

This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.

bioRxiv · May 18, 2021Immunology

A cell-topography based mechanism for ligand discrimination by the T-cell receptor

R. A. Fernandes, K. A. Ganzinger, J. Tzou, P. Jonsson, S. F. Lee, M. Palayret, A. M. Santos, A. A. Carr, A. Ponjavic, V. T. Chang, C. Macleod, B. C. Lagerholm, A. E. Lindsay, O. Dushek, A. Tilevik, , D. Klenerman

This paper develops a model showing T-cell receptors discriminate ligands based on dwell-time in phosphatase-depleted contacts constrained by cell topography, predicting signaling potency without multi-step proof-reading.

Proceedings of the National Academy of Sciences · Jun 20, 2019Peer-reviewedImmunology