Author

J. J. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Animal Behavior & Cognition· 1 Evolutionary Biology· 1 Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:behavioral assay· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Kipar· 4 shared A. Owen· 4 shared J. A. Hiscox· 4 shared J. P. Stewart· 4 shared P. Sharma· 4 shared E. I. Patterson· 3 shared G. Hughes· 3 shared E. Bentley· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

A. Kipar

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Levodopa reduces consumption of multiple classes of addictive substances in rats

R. D. Farero, N. A. Holtz, S. J. Lee, L. C. Kruse, J. J. Clark, P. E. M. Phillips

This study shows that L-DOPA reduces alcohol and opioid self-administration in rats, suggesting a role for dopamine signaling in drug consumption across multiple substance classes.

bioRxiv · Dec 14, 2023 · PreprintAnimal Behavior & Cognition

Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice

R. Salzer, J. J. Clark, M. Vaysburd, V. T. Chang, A. Albecka, L. Kiss, P. Sharma, A. Gonzalez Llamazares, A. Kipar, J. A. Hiscox, A. Owen, A. R. Aricescu, J. P. Stewart, L. C. James, J. Lowe

This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.

bioRxiv · May 18, 2021Immunology

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

F. Seehusen, J. J. Clark, P. Sharma, E. Bentley, A. Kirby, K. Subramaniam, S. Wunderlin Giuliani, G. Hughes, E. I. Patterson, B. D. Michael, A. Owen, J. A. Hiscox, J. P. Stewart, A. Kipar

This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.

bioRxiv · Apr 16, 2021Pathology

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

J. J. Clark, P. Sharma, E. Bentley, A. C. Harding, A. Kipar, M. Neary, H. Box, G. Hughes, E. I. Patterson, J. Sharp, T. de Oliveira, A. Sigal, J. A. Hiscox, W. S. James, M. W. Carroll, , J. P. Stewart

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

J. J. Clark, R. Penrice-Randal, P. Sharma, A. Kipar, X. Dong, S. Pennington, A. E. Marriott, S. Colombo, A. D. Davidson, M. Kavanagh Williamson, D. A. Matthews, L. Turtle, T. Prince, G. Hughes, E. I. Patterson, , J. P. Stewart

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

bioRxiv · Oct 13, 2020 · PreprintMicrobiology

Population genomics of louping ill virus provide new insights into the evolution of tick-borne flaviviruses

J. J. Clark, J. Gilray, R. J. Orton, M. Baird, G. S. Wilkie, A. da Silva Filipe, N. Johnson, C. J. McInnes, A. Kohl, R. Biek

This study sequences 22 louping ill virus isolates to analyze genomic diversity and evolutionary history, finding low diversity, limited positive selection, and challenges in estimating molecular clock rates for tick-borne flaviviruses.

bioRxiv · Feb 14, 2020Evolutionary Biology

Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain

E. J. Y. Leung, A. D. Abraham, B. A. Wong, L. C. Kruse, J. J. Clark, B. B. Land

This study shows that mice voluntarily consume cannabinoids and opioids via gelatin, with cannabinoids providing long-term relief of chronic neuropathic pain.

bioRxiv · Feb 21, 2019Pharmacology & Toxicology